CTLA4 (Cytotoxic TLymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the Tcell costimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B71 and B72 respectively, on antigenpresenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4Ig) have been used in clinical trials for rheumatoid arthritis. - Proteine/Peptide
Immobilized Monoclonal Anti-Human CTLA-4 Antibody, Human IgG1 (Cat. No. CT4-M1203) at 2 µg/mL (100 µL/well) can bind Biotinylated Cynomolgus / Rhesus macaque CTLA-4 Protein, Fc,Avitag (Cat. No. CT4-C82F3) with a linear range of 0.1-2 ng/mL (QC tested).
Immobilized Cynomolgus / Rhesus macaque B7-1, Fc Tag (Cat. No. CD0-C5252) at 2 µg/mL (100 µL/well) can bind Biotinylated Cynomolgus / Rhesus macaque CTLA-4 Protein, Fc,Avitag (Cat. No. CT4-C82F3) with a linear range of 0.1-2 ng/mL (Routinely tested).
Biotinylated Cynomolgus / Rhesus macaque CTLA-4 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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