Biotinylated Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1, Multiple

Produktübersicht

• Artikelname: Biotinylated Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1, Multiple
• Artikelnummer: ABS-DM1-BLY73-200UG
• Hersteller Artikelnummer: DM1-BLY73-200ug
• Alternativnummer: ABS-DM1-BLY73-200UG
• Hersteller: AcroBiosystems
• Wirt: Multiple
• Kategorie: Antikörper
• Spezies Reaktivität: Mouse
• Konjugation: Biotin

Produktbeschreibung

Mertansine (DM1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alphaamino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM1, derived from Mydenin, is a cytotoxic component of antibodydrug conjugations that produce antibodydrug conjugations via a sulfhydryl group splice with SPP (nsuccinimide 4 (2pyridyl dithio)) or SMCC (4 (3mercapto2, 5dioxy1 pyrrolidyl) cyclohexanic acid) splice. - Antikörper

Produkteigenschaften

• Tag: Mouse IgG1 | Mouse Kappa
• Puffer: PBS, pH7.4
• Formulierung: Powder
• Target-Kategorie: DM-1

Bilder

Immobilized Trastuzumab-DM1 (T-DM1) at 2 µg/mL (100 µL/well) can bind Biotinylated Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1 (MALS verified) (Cat. No. DM1-BLY73) with a linear range of 0.98-31.25 ng/mL (QC tested).

Immobilized Human Her2 / ErbB2 (498-648) Protein, His Tag (Cat. No. HE2-H52H4) at 2 µg/mL, add increasing concentrations of Trastuzumab-DM1 (T-DM1), and then add Biotinylated Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1 (MALS verified) (Cat. No. DM1-BLY73) at 0.5 µg/mL. Detection was performed using HRP-conjugated streptavidin with sensitivity of 1.95 ng/mL (Routiney tested).