Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag(TM), Human

Produktübersicht

• Artikelname: Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag(TM), Human
• Artikelnummer: ABS-DXD-BVM807-200UG
• Hersteller Artikelnummer: DXD-BVM807-200ug
• Alternativnummer: ABS-DXD-BVM807-200UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Antikörper
• Spezies Reaktivität: Mouse
• Konjugation: Biotin

Produktbeschreibung

Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS8201A). Dxd was cytotoxic to human tumor cell lines KPL4, NCIN87 and SKBR, 3 and the IC50s of MDAMB468 was 1.43 NM4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2positive KPL4 and NCI cell lines N87 and SKBRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB468 (IC50, > 10000 mL). HRPantiDXDantibody is a conjugation product of HRP and antiDXDantibody. It can be used in PK, PD analysis and ELISA. - Antikörper

Produkteigenschaften

• Tag: Mouse IgG1 | Mouse Kappa
• Puffer: PBS, pH7.4
• Reinheit: 0.9
• Formulierung: Powder
• Target-Kategorie: DXD

Bilder

Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 µg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag (Cat. No. DXD-BVM807) at 0.05 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

Immobilized Trastuzumab Deruxtecan at 1 µg/mL (100 µL/well) can bind Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag (Cat. No. DXD-BVM807) with a linear range of 0.5-8 ng/mL (Routinely tested).

Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 0.9.