Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag (MALS&SPR verified), Unconjugated, Insect
Artikelnummer:
ABS-ELL-H5595-100UG
Hersteller Artikelnummer:
ELL-H5595-100ug
Alternativnummer:
ABS-ELL-H5595-100UG
Hersteller:
AcroBiosystems
Wirt:
Insect
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complexa general transcription elongation factor that increases RNA Polymerase II transcription through templateencoded arresting sites. The ELOB/ELOC complex also binds to the BCbox motif found in many proteins in the VHLbox and SOCSbox protein families. In this function, ELOB/ELOC serves as an adapter between substrate recognition proteins and either Cullin2/Rbx1 (in VHLbox E3 Ubiquitin ligases) or Cullin5/Rbx2 (in SOCSbox E3 Ubiquitin ligases). VHL is involved in the ubiquitination and subsequent proteasomal degradation via the von HippelLindau ubiquitination complex. It seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxiainducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. - Proteine/Peptide
Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
ELL-H5595-100ug
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