Human ENPP3 / CD203c Protein, His Tag (active enzyme), Unconjugated

Produktübersicht

• Artikelname: Human ENPP3 / CD203c Protein, His Tag (active enzyme), Unconjugated
• Artikelnummer: ABS-EN3-H52H4-1MG
• Hersteller Artikelnummer: EN3-H52H4-1mg
• Alternativnummer: ABS-EN3-H52H4-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotidedegrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigenbound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response). - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 96.9 kDa
• Tag: N-10*His
• NCBI: 14638
• Puffer: 50 mM Tris, 150 mM NaCl, pH8.0
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: ENPP3

Bilder

Human ENPP3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.