Receptor tyrosineprotein kinase erbB4 (ErbB4), also known as Her4, is a singlepass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furinlike cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins2 and 3, heparinbinding EGFlike growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. ERBB4 has been shown to interact with: DLG4, NRG1, STAT5A, and YAP1. Mutations in this gene have been associated with cancer. Other singlenucleotide polymorphisms and a risk haplotype have been linked to schizophrenia. - Proteine/Peptide
Immobilized Human ErbB4, His Tag (Cat. No. ER4-H5221) at 2 µg/mL (100 µL/well) can bind Human NRG1 Beta 1, Fc Tag, premium grade (Cat. No. NR1-H5268) with a linear range of 0.5-8 ng/mL (QC tested).
Human ErbB4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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