Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-ERR-H5255-1MG
• Hersteller Artikelnummer: ERR-H5255-1mg
• Alternativnummer: ABS-ERR-H5255-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Epo (Erythropoietin) is the primary regulator of erythropoiesis and is critical for tissue oxygenation under both steadystate conditions and after acute blood loss or hypoxia. The EPO R is the primary receptor that binds to and transmits the activation signal of the EPO cytokine.ERO R is a member of the type I cytokine receptor superfamily. It usually exists as a homodimer and expressed extensively in EPOresponsive BM erythroid progenitors (BFUE and CFUE). The interaction of EPO with EPO R at the level of proerythroid cells activates proliferation, increases survival and promotes cellrestricted lineage erythroid differentiation. EPO also binds to the heterodimeric complex EPOR on nonerythroid tissues (brain, heart, retina, kidney and others). This heterodimeric complex consists of one chain of EPOR and a ubiquitous colonystimulating factor 2 receptor betachain (CD131). This heterodimeric receptor has been called the tissue protective receptor (TPR) of EPO. Although the interaction of EPO with TPR does not initiate erythropoiesis, it signals biochemical cascades (activation of PI3K, MARK, STAT5 and others), leading to the protection of cells from apoptosis, degeneration and cytotoxicity in general. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 51.3 kDa & 74.9 kDa
• Tag: C-Fc | C-Fc
• NCBI: 19235
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: Erythropoietin R & CD131

Bilder

Immobilized Human EPO Protein, premium grade (Cat. No. EPO-H4214) at 10 µg/mL (100 µL/well) can bind Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag (Cat. No. ERR-H5255) with a linear range of 0.6-78 ng/mL (QC tested).

Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.