Cluster of Differentiation 31 (CD31) is also known as Platelet endothelial cell adhesion molecule (PECAM1), is a 130kDa transmembrane glycoprotein expressed by endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils, certain tumors, and is the only known member of the CAM family on platelets. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of Tcells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. CD31 plays a key role in removing aged neutrophils from the body. CD31 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin alphavbeta3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is upregulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages. - Antikörper
Tag:
Mouse IgG1 | Mouse kappa
Puffer:
PBS, pH7.4, 0.03% Proclin300, 0.2% BSA
Formulierung:
Liquid
Target-Kategorie:
CD31
Anwendungsbeschreibung:
Flow Cytometry (Evaluation of the expression of CD31 on Human cells).
FABm033-01-200tests
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