Human FAP Protein, His Tag, active dimer (MALS verified), Unconjugated
Artikelnummer:
ABS-FAP-H5244-100UG
Hersteller Artikelnummer:
FAP-H5244-100ug
Alternativnummer:
ABS-FAP-H5244-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit postproline cleaving endopeptidase activity, with a marked preference for Ala/SerGlyProSer/Asn/Ala consensus sequences. Degrade also gelatin, heatdenatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for AlaPro, IlePro, GlyPro, ArgPro and ProPro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activityindependent manner. - Proteine/Peptide
Immobilized Human FAP, His Tag (Cat. No. FAP-H5244) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-FAP (FAP5) Antibody, Mouse IgG2a with a linear range of 0.1-2 ng/mL (QC tested).
Immobilized Human FAP, His Tag (Cat. No. FAP-H5244) at 1 µg/mL (100 µL/well) can bind Anti-FAP (Sibrotuzumab) Antibody,Human IgG1 with a linear range of 0.1-2 ng/mL (Routinely tested).
Human FAP, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
FAP-H5244-100ug
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