Human FGF19 Protein, Mouse IgG2a Fc Tag, Unconjugated

Produktübersicht

• Artikelname: Human FGF19 Protein, Mouse IgG2a Fc Tag, Unconjugated
• Artikelnummer: ABS-FG9-H5254-100UG
• Hersteller Artikelnummer: FG9-H5254-100ug
• Alternativnummer: ABS-FG9-H5254-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Fibroblast Growth Factor 19 (FGF19) is a hormone belonging to the FGF family, encoded by the FGF19 gene. It is primarily synthesized and secreted in the ileum in response to bile acid absorption, acting as a ligand for the farnesoid X receptor (FXR). FGF19s core function is to exert negative feedback on hepatic bile acid synthesis by binding to the Fibroblast Growth Factor Receptor 4 (FGFR4)/Klothobeta complex in the liver, thereby inhibiting cholesterol 7alphahydroxylase (CYP7A1). Additionally, it plays a role in glucose and lipid metabolism. Its mouse ortholog is FGF15, and they are often referred to collectively as FGF15/19. Altered FGF19 levels are implicated in chronic bile acid diarrhea and certain metabolic disorders. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 48.3 kDa
• Tag: C-mFc(mIgG2a)
• NCBI: 95750
• Puffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: FGF19

Bilder

Human FGF19 Protein, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.