Human FGF19 Protein, Mouse IgG2a Fc Tag, Unconjugated
Artikelnummer:
ABS-FG9-H5254-1MG
Hersteller Artikelnummer:
FG9-H5254-1mg
Alternativnummer:
ABS-FG9-H5254-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Fibroblast Growth Factor 19 (FGF19) is a hormone belonging to the FGF family, encoded by the FGF19 gene. It is primarily synthesized and secreted in the ileum in response to bile acid absorption, acting as a ligand for the farnesoid X receptor (FXR). FGF19s core function is to exert negative feedback on hepatic bile acid synthesis by binding to the Fibroblast Growth Factor Receptor 4 (FGFR4)/Klothobeta complex in the liver, thereby inhibiting cholesterol 7alphahydroxylase (CYP7A1). Additionally, it plays a role in glucose and lipid metabolism. Its mouse ortholog is FGF15, and they are often referred to collectively as FGF15/19. Altered FGF19 levels are implicated in chronic bile acid diarrhea and certain metabolic disorders. - Proteine/Peptide
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Reinheit:
90%
Formulierung:
Powder
Target-Kategorie:
FGF19
Human FGF19 Protein, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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