Mouse FGF R2 (IIIb) protein, His Tag, Unconjugated, Human

Produktübersicht

• Artikelname: Mouse FGF R2 (IIIb) protein, His Tag, Unconjugated, Human
• Artikelnummer: ABS-FGB-M52H5-100UG
• Hersteller Artikelnummer: FGB-M52H5-100ug
• Alternativnummer: ABS-FGB-M52H5-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Mouse
• Konjugation: Unconjugated

Produktbeschreibung

Tyrosineprotein kinase that acts as cellsurface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is downregulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Overexpressed FGFR2 promotes activation of STAT1. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 24.8 kDa
• Tag: C-10*His
• NCBI: 21803
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: FGF R2 (IIIb)

Bilder

Immobilized Mouse FGFR2 (IIIb), His Tag (Cat. No. FGB-M52H5) at 5 µg/mL (100 µL/well) can bind Biotinylated Human FGF basic, Avitag,His Tag (Cat. No. FGC-H81E3) with a linear range of 0.039-1.25 µg/mL (QC tested).

Mouse FGFR2 (IIIb), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.