Human FUS Protein, MBP,His Tag, Unconjugated, E. coli
Artikelnummer:
ABS-FUS-H5144-1MG
Hersteller Artikelnummer:
FUS-H5144-1mg
Alternativnummer:
ABS-FUS-H5144-1MG
Hersteller:
AcroBiosystems
Wirt:
E. coli
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
FUS (RNAbinding protein FUS) is a DNA/RNAbinding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent premRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own premRNA and autoregulates its expression, this autoregulation mechanism is mediated by nonsensemediated decay. FUS plays a role in DNA repair mechanisms by promoting Dloop formation and homologous recombination during DNA doublestrand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. - Proteine/Peptide
