GDNF family receptor alpha1 (GFRA1) is also known as RET ligand 1 (RETL1), TGFbetarelated neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)linked cell surface receptor, and belongs to the glial cell linederived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alphamediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas. - Proteine/Peptide
Immobilized Human GDNF Protein, premium grade (Cat. No. GDF-H5219) at 2 µg/mL (100 µL/well) can bind Human GFR alpha-1 Protein, His Tag (Cat. No. GF1-H5224) with a linear range of 0.5-2 ng/mL (Routinely tested).
Human GFR alpha-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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