Human GITR Ligand / TNFSF18 Protein, Fc Tag, Unconjugated
Artikelnummer:
ABS-GIL-H526A-1MG
Hersteller Artikelnummer:
GIL-H526a-1mg
Alternativnummer:
ABS-GIL-H526A-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid induced TNFrelated ligand (GITRL or GITR Ligand), Activation inducible TNF related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is upregulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for Tcell activation and Tcell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated Tlymphocytes and endothelial cells. TNFSF18 also mediates activation of NFkappaB. - Proteine/Peptide
