Biotinylated Human GM-CSF Protein, His,Avitag(TM) (HPLC verified)

Produktübersicht

• Artikelname: Biotinylated Human GM-CSF Protein, His,Avitag(TM) (HPLC verified)
• Artikelnummer: ABS-GMF-H82E3-200UG
• Hersteller Artikelnummer: GMF-H82E3-200ug
• Alternativnummer: ABS-GMF-H82E3-200UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Biotin

Produktbeschreibung

Granulocytemacrophage colonystimulating factor (GMCSF) is also known as Colony stimulating factor 2 (granulocytemacrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GMCSF is a cytokine that functions as a white blood cell growth factor. GMCSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GMCSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GMCSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GMCSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIVinfected patients. The preliminary results have been promising. GMCSF is also used as a medication to stimulate the production of white blood cells following chemotherapy. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 18.1 kDa
• Tag: C-10*His & C-Avi
• NCBI: 000749
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: GM-CSF

Bilder

GMF-H82E3-200ug

Immobilized Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) at 1 µg/mL (100 µL/well) can bind Biotinylated Human GM-CSF Protein, His,Avitag (Cat. No. GMF-H82E3) with a linear range of 0.6-20 ng/mL (QC tested).

Biotinylated Human GM-CSF Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.