Mouse GM-CSF Protein, Tag Free, Unconjugated, Human
Artikelnummer:
ABS-GMF-M5211-50UG
Hersteller Artikelnummer:
GMF-M5211-50ug
Alternativnummer:
ABS-GMF-M5211-50UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Mouse
Konjugation:
Unconjugated
Granulocytemacrophage colonystimulating factor (GMCSF) is also known as Colony stimulating factor 2 (granulocytemacrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GMCSF is a cytokine that functions as a white blood cell growth factor. GMCSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GMCSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GMCSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GMCSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIVinfected patients. The preliminary results have been promising. GMCSF is also used as a medication to stimulate the production of white blood cells following chemotherapy. - Proteine/Peptide
