Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositollinked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin1. GPC2 silencing inactivates Wnt/betacatenin signaling and reduces the expression of NMyc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation. - Proteine/Peptide
