Human IDH1 (R132C) Protein, His Tag (MALS verified), Unconjugated, E. coli 500 ug

Produktübersicht

• Artikelname: Human IDH1 (R132C) Protein, His Tag (MALS verified), Unconjugated, E. coli 500 ug
• Artikelnummer: ABS-ID1-H51H8-500UG
• Hersteller Artikelnummer: ID1-H51H8-500ug
• Alternativnummer: ABS-ID1-H51H8-500UG
• Hersteller: AcroBiosystems
• Wirt: E. coli
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alphaketoglutarate (alphaKG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NADdependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADPdependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADPdependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha -ketoglutarate, but the enzyme acquires the ability to generate 2hydroxyglutarate (2HG) from alpha-ketoglutarate,2HG is elevated in several tumor types, including a subset of AMLs. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 48.5 kDa
• Tag: C-10*His
• NCBI: 75874
• Puffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Liquid
• Target-Kategorie: IDH1

Bilder

Human IDH1 (R132C), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.