Interferongamma (IFNgamma/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophageactivating factor, a term now used to describe a larger family of proteins to which IFNgamma belongs. IFNgamma has been used in a wide variety of clinical indications. Interferongamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNGmediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression. - Antikörper
Tag:
Mouse IgG2a | Mouse Kappa
Puffer:
PBS, pH7.4
Reinheit:
0.95
Formulierung:
Powder
Target-Kategorie:
IFN-gamma
Immobilized Human IFN-gamma, premium grade (Cat. No. IFG-H4211) can bind Monoclonal Anti-IFNgamma antibody, Mouse IgG2a (8C5F8) (Cat. No. IFN-S120) with a linear range of 0.02-25 ng/mL (QC tested).
Monoclonal Anti-IFNgamma Antibody, Mouse IgG2a (8C5F8) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 0.95.
IFN-S120-100ug
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