Interleukin23 subunit alpha (IL23 alpha) can associates with IL12B to form the IL23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL23 may constitute with IL17 an acute response to infection in peripheral tissues. IL23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JakStat signaling cascade, stimulates memory rather than naive Tcells and promotes production of proinflammatory cytokines. IL23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. - Proteine/Peptide
Immobilized Biotinylated Cynomolgus IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-C82W3) at 0.5 µg/mL (100 µL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 µg/well) plate can bind Cynomolgus IL-23 R, Fc Tag (Cat. No. ILR-C5251) with a linear range of 0.05-3 ng/mL (QC tested).
Immobilized Biotinylated Cynomolgus IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-C82W3) at 0.5 µg/mL (100 µL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 µg/well) plate can bind Guselkumab (CNTO 1959) with a linear range of 0.05-2 ng/mL (Routinely tested).
Biotinylated Cynomolgus IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
ILB-C82W3-25ug
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