Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free, Unconjugated
Artikelnummer:
ABS-IT3-H52W8-1MG
Hersteller Artikelnummer:
IT3-H52W8-1mg
Alternativnummer:
ABS-IT3-H52W8-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces insideout signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outsidein signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligandinduced binding sites (LIBS), which are recognized by antiLIBS monoclonal antibodies. - Proteine/Peptide
Immobilized Human Fibronectin at 2 µg/mL (100 µL/well) can bind Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52W8) with a linear range of 2-78 ng/mL (QC tested).
Immobilized Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52W8) at 1 µg/mL (100 µL/well) can bind Abciximab with a linear range of 0.8-6 ng/mL (Routinely tested).
Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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