Kremens are highaffinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/betacatenin signaling pathway by downregulating the lowdensity lipoprotein receptorrelated protein 6 (LRP6). Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CVA10), a causative agent of handfootandmouth disease (HFMD). - Proteine/Peptide
Immobilized Human Dkk-1, His Tag (Cat. No. DK1-H5221) at 2 µg/mL (100 µL/well) can bind Human Kremen-1, Fc Tag (Cat. No. KR1-H5253) with a linear range of 0.02-0.313 µg/mL (QC tested).
Human Kremen-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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