Receptor for Rspondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to Rspondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical Gprotein coupled receptors, does not activate heterotrimeric Gproteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. - Proteine/Peptide
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Reinheit:
90%
Formulierung:
Powder
Target-Kategorie:
LGR5
Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 µg/mL (100 µL/well) can bind Human LGR5 protein, Fc Tag (Cat. No. LG5-H5253) with a linear range of 0.3-10 ng/mL (QC tested).
Immobilized Human LGR5 protein, Fc Tag (Cat. No. LG5-H5253) at 5 µg/mL (100 µL/well) can bind Human R-Spondin 3 (22-146), His Tag (Cat. No. RS6-H5222) with a linear range of 1-20 ng/mL (Routinely tested).
Human LGR5 protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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