Leukemia inhibitory factor receptor is also known as LIFR, CD118, FLJ98106, FLJ99923, LIFR, SJS2, STWS, SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a highaffinity receptor complex composed of a lowaffinity LIF binding chain (LIF receptor) and a highaffinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of StueveWiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bentbone dysplasias. - Proteine/Peptide
