The protein encoded by this gene is a serine proteinase that inhibits the activity of tissuetype plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 243 copies of kringletype domains. The allele represented here contains 15 copies of the kringletype repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009] - Proteine/Peptide
Human LPA Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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