Biotinylated Human LRRC15 / LIB Protein, His,Avitag(TM) (MALS verified)

Produktübersicht

• Artikelname: Biotinylated Human LRRC15 / LIB Protein, His,Avitag(TM) (MALS verified)
• Artikelnummer: ABS-LR5-H82E4-200UG
• Hersteller Artikelnummer: LR5-H82E4-200ug
• Alternativnummer: ABS-LR5-H82E4-200UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Biotin

Produktbeschreibung

LRRC15 (Leucinerich repeatcontaining protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFbeta on activated fibroblasts (alphaSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15positive stromal desmoplasia or cancers of mesenchymal origin. ABBV085 is a monomethyl auristatin E (MMAE)containing antibody-drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromalpositive/cancernegative, and LRRC15 cancerpositive models as a monotherapy, or in combination with standardofcare therapies. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 61.5 kDa
• Tag: C-10*His & C-Avi
• NCBI: 8
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: LRRC15

Bilder

Immobilized Samrotamab at 1 µg/mL (100 µL/well) can bind Biotinylated Human LRRC15, His,Avitag (Cat. No. LR5-H82E4) with a linear range of 1-78 ng/mL (QC tested).

Biotinylated Human LRRC15, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.