Cynomolgus MMP-7 Protein, His Tag (active enzyme, HPLC verified), Unconjugated 1 mg

Produktübersicht

• Artikelname: Cynomolgus MMP-7 Protein, His Tag (active enzyme, HPLC verified), Unconjugated 1 mg
• Artikelnummer: ABS-MM7-C53H3-1MG
• Hersteller Artikelnummer: MM7-C53H3-1mg
• Alternativnummer: ABS-MM7-C53H3-1MG
• Hersteller: AcroBiosystems
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Monkey
• Konjugation: Unconjugated

Produktbeschreibung

MMP7 (matrilysin), the smallest zincdependent endopeptidase in the MMP family, lacks a hemopexin domain but features a catalytic zincbinding motif (HEXXHXXGXXH) critical for degrading extracellular matrix (ECM) components, including collagens III/IV/V, elastin, and proteoglycans. Activated via proteolytic cleavage (e.g., by MMP3), it promotes tissue remodeling in wound healing while driving pathological processes such as tumor invasion (via Ecadherin degradation and Wnt/betacatenin activation) and fibrosis (via betacateninmediated renal damage). Overexpressed in epithelial cancers, MMP7 correlates with metastasis but paradoxically shows protective genetic variants in some contexts. It also processes nonECM substrates like TNFalpha and Fas ligand, amplifying inflammation and oncogenesis. In fibrotic diseases, elevated serum MMP7 predicts progression, serving as a diagnostic biomarker. Therapeutic strategies targeting MMP7, including inhibitors and monoclonal antibodies, highlight its dual roles as both a driver of ECM disruption and a modulator of immunetumor interactions. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 29.9 kDa
• Tag: C-10*His
• NCBI: 7
• Puffer: 10 mM HEPES, 150 mM NaCl, pH7.5
• Reinheit: 90%
• Formulierung: Liquid
• Target-Kategorie: MMP-7

Bilder

Cynomolgus MMP-7 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.