Human IL-12A / NKSF1 / p35 Protein, Fc Tag, Unconjugated

Produktübersicht

• Artikelname: Human IL-12A / NKSF1 / p35 Protein, Fc Tag, Unconjugated
• Artikelnummer: ABS-NK1-H5252-500UG
• Hersteller Artikelnummer: NK1-H5252-500ug
• Alternativnummer: ABS-NK1-H5252-500UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Interleukin12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL12A (p35) and IL12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human Blymphoblastoid cells (NC37) in response to antigenic stimulation. IL12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL12 also has antiangiogenic activity, which means it can block the formation of new blood vessels. Interleukin12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL6, GCSF, and exerts biological activities only when the IL12B is coexpressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knockout mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 49.2 kDa
• Tag: C-Fc
• NCBI: 29459
• Puffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: IL-12A

Bilder

Human IL-12A, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.