Human NOTCH2 Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human NOTCH2 Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-NO2-H5255-100UG
• Hersteller Artikelnummer: NO2-H5255-100ug
• Alternativnummer: ABS-NO2-H5255-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Functions as a receptor for membranebound ligands Jagged1 (JAG1), Jagged2 (JAG2) and Delta1 (DLL1) to regulate cellfate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKLinduced osteoclast differentiation . Positively regulates selfrenewal of liver cancer cells . - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 80.5 kDa
• Tag: C-Fc
• NCBI: 04721
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: NOTCH2

Bilder

NO2-H5255-100ug

Immobilized Human DLL4, His Tag (Cat. No. DL4-H5227) at 5 µg/mL (100 µL/well) can bind Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) with a linear range of 5-78 ng/mL (QC tested).

Immobilized Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) at 1 µg/mL (100 µL/well) can bind Bispecific Antibody (NOTCH2 * NOTCH3) with a linear range of 1-20 ng/mL (Routinely tested).

Human NOTCH2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.