Human NY-ESO-1 TCR & CD3E & CD3D & CD3G & CD3Z Full Length Protein Complex (VLP), Unconjugated
Artikelnummer:
ABS-NYZ-H5213-20UG
Hersteller Artikelnummer:
NYZ-H5213-20ug
Alternativnummer:
ABS-NYZ-H5213-20UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Cluster of Differentiation 3 (CD3) is a pivotal multimeric T cell coreceptor complex essential for adaptive immune responses. Composed of epsilon (epsilon), gamma (gamma), delta (delta), and zeta (zeta) polypeptide chains forming three distinct dimers (epsilongamma, epsilondelta, zetazeta), CD3 noncovalently associates with the Tcell receptor (TCR) to establish the critical TCR/CD3 receptor complex on T cell surfaces. Structurally, CD3 proteins belong to the immunoglobulin superfamily, featuring a transmembrane domain, an Nterminal extracellular region with immunoglobulinlike domains, and cytoplasmic tails embedded with immunoreceptor tyrosinebased activation motifs (ITAMs). These ITAMs are fundamental for initiating signal transduction upon T cell receptor engagement, thereby activating both CD4+ T helper and CD8+ cytotoxic T cells. As a defining marker of the T cell lineage, CD3s central role in T cell activation makes its modulation, via stimulating or blocking antibodies, a promising therapeutic avenue for conditions like organ transplant rejection and autoimmune diseases. - Proteine/Peptide
