Human PCSK9 (D374Y) Protein, His Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human PCSK9 (D374Y) Protein, His Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-PCY-H5225-1MG
• Hersteller Artikelnummer: PCY-H5225-1mg
• Alternativnummer: ABS-PCY-H5225-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factorlike repeat A (EGFA) domain of the lowdensity lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 13.8 kDa and 58.2 kDa
• Tag: C-6*His
• NCBI: 8
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: PCSK9

Bilder

Immobilized Human LDL R, Fc Tag at 2 µg/mL (100 µL/well) can bind Human PCSK9 (D374Y), His Tag (Cat. No. PCY-H5225) with a linear range of 20-78 ng/mL (QC tested).

Immobilized Human PCSK9 (D374Y), His Tag (Cat. No. PCY-H5225) at 1 µg/mL (100 µL/well) on Monoclonal Anti-His Tag Antibody, Mouse IgG1 (AY63) precoated (0.1 µg/well) plate can bind Evolocumab with a linear range of 0.1-4 ng/mL (Routinely tested).

PCY-H5225-1mg

Human PCSK9 (D374Y), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.