Human PD-1 / PDCD1 Protein, His Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human PD-1 / PDCD1 Protein, His Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-PD1-H5221-1MG
• Hersteller Artikelnummer: PD1-H5221-1mg
• Alternativnummer: ABS-PD1-H5221-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Programmed cell death protein 1 (PD1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD1 has two ligands, PDL1 and PDL2, which are members of the B7 family. PDL1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFNgamma. PDL2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the Tcell proliferation and production of related cytokines including IL1, IL4, IL10 and IFNgamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCRmediating signal by dephosphorylating key signal transducer. In vitro, treatment of antiCD3 stimulated T cells with PDL1Ig results in reduced T cell proliferation and IFNgamma secretion. Monoclonal antibodies targeting PD1 that boost the immune system are being developed for the treatment of cancer. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 16.8 kDa
• Tag: C-6*His
• NCBI: 005009
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: PD-1

Bilder

Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 µg/mL (100 µL/well) can bind Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5) with a linear range of 10-156 ng/mL (Routinely tested).

Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 µg/mL (100 µL/well) can bind Nivolumab with a linear range of 0.1-3 ng/mL (Routinely tested).

Human PD-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

PD1-H5221-1mg