Human PD-L2 / B7-DC Protein, Mouse IgG1 Fc Tag, Unconjugated

Produktübersicht

• Artikelname: Human PD-L2 / B7-DC Protein, Mouse IgG1 Fc Tag, Unconjugated
• Artikelnummer: ABS-PD2-H52A5-1MG
• Hersteller Artikelnummer: PD2-H52A5-1mg
• Alternativnummer: ABS-PD2-H52A5-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Programmed cell death 1 ligand 2 (PDL2 or PDCD1 ligand 2) is also known as Butyrophilin B7DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PDL2 is upregulated by IFNG/IFNgamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4. PDL2 Involved in the costimulatory signal, essential for Tcell proliferation and IFNG production in a PDCD1independent manner. PDL2 interaction with PDCD1 inhibits Tcell proliferation by blocking cell cycle progression and cytokine production. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 48.9 kDa
• Tag: C-mFc(mIgG1)
• NCBI: 13679
• Puffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: PD-L2

Bilder

Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 µg/mL (100 µL/well) can bind Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5) with a linear range of 10-156 ng/mL (QC tested).

Serial dilutions of nivolumab were added into Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5): Biotinylated Human PD-1, Fc,Avitag (Cat. No. PD1-H82F1) binding reactions. The half maximal inhibitory concentration (IC50) is 0.2823 µg/mL (Routinely tested).

PD2-H52A5-1mg

Human PD-L2, Mouse IgG1 Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.