Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11), Unconjugated, Human

Produktübersicht

• Artikelname: Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11), Unconjugated, Human
• Artikelnummer: ABS-PNU-MY2372-100UG
• Hersteller Artikelnummer: PNU-MY2372-100ug
• Alternativnummer: ABS-PNU-MY2372-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Antikörper
• Spezies Reaktivität: Rabbit
• Konjugation: Unconjugated

Produktbeschreibung

PNU159682 is a topoisomerase II inhibitor serving as a payload for antibodydrug conjugates (ADCs). Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression. - Antikörper

Produkteigenschaften

• Tag: Rabbit IgG | Rabbit Kappa
• Puffer: PBS, pH7.4
• Formulierung: Powder
• Target-Kategorie: PNU-159682

Bilder

Immobilized Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372) at 1 µg/mL (100 µL/well) can bind ADC-PNU-159682 with a linear range of 2-125 ng/mL (QC tested).

Serial dilutions of PNU-159682 were added into Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372): Human IgG1 Kappa Isotype Control (mAb) (Cat. No. DNP-M2) binding reactions. The half maximal inhibitory concentration (IC50) is 2.31 ng/mL (Routinely tested).