Human TNFSF11 / RANKL / CD254 Protein, His Tag, active trimer (MALS verified), Unconjugated
Artikelnummer:
ABS-RAL-H5240-1MG
Hersteller Artikelnummer:
RAL-H5240-1mg
Alternativnummer:
ABS-RAL-H5240-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Receptor activator of nuclear factor kappaB ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNFrelated activationinduced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG. - Proteine/Peptide
Immobilized Human TNFSF11 Protein, His Tag (Cat. No. RAL-H5240) at 2 µg/mL (100 µL/well) can bind Human RANK Protein, Mouse IgG2a Fc Tag (Cat. No. RAK-H5251) with a linear range of 0.2-5 ng/mL (QC tested).
Immobilized Human OPG, Fc Tag (Cat. No. TNB-H5259) at 2 µg/mL (100 µL/well) can bind Human TNFSF11 Protein, His Tag (Cat. No. RAL-H5240) with a linear range of 0.2-2 ng/mL (Routinely tested).
Human TNFSF11 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
RAL-H5240-1mg
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