Tyrosineprotein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptorrelated 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Iglike C2type (immunoglobulinlike) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1epsilon) to activate phosphoinositide 3kinasemediated AKT phosphorylation and cAMPresponseelementbinding protein (CREB), which was associated with enhanced tumorcell growth. - Proteine/Peptide
Immobilized Anti-ROR1 Antibody, Human IgG1 at 1 µg/mL (100 µL/well) can bind FITC-Labeled Human ROR1, His Tag (Cat. No. RO1-HF258) with a linear range of 0.078-1.25 µg/mL (QC tested).
RO1-HF258-200ug
FITC-Labeled Human ROR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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