Human R-Spondin 3 / RSPO3 (22-146) Protein, His Tag, Unconjugated

Produktübersicht

• Artikelname: Human R-Spondin 3 / RSPO3 (22-146) Protein, His Tag, Unconjugated
• Artikelnummer: ABS-RS6-H5222-50UG
• Hersteller Artikelnummer: RS6-H5222-50ug
• Alternativnummer: ABS-RS6-H5222-50UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

RSpondin 3 (RSPO3) is also called cysteinerich and single thrombospondin domain containing1 (CRISTIN1), Protein with TSP type1 repeat (PWTSR), is a member of the Rspondin protein family. Rspondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the betacatenin signaling cascade, leading to TCFdependent gene activation. RSPO3 acts both in the canonical Wnt/betacatenindependent pathway and in noncanonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGFbeta pathway. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 15.9 kDa
• Tag: C-8*His
• NCBI: 22367
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: R-Spondin 3

Bilder

Human R-Spondin 3 (22-146), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

RS6-H5222-50ug