Human Sonic Hedgehog / Shh (C24II) Protein, premium grade, Unconjugated, E. coli
Artikelnummer:
ABS-SH7-H5116-1MG
Hersteller Artikelnummer:
SH7-H5116-1mg
Alternativnummer:
ABS-SH7-H5116-1MG
Hersteller:
AcroBiosystems
Wirt:
E. coli
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Sonic hedgehog protein (SHH) is also known as HHG1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein Nproduct and sonic hedgehog protein Cproduct by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The Cterminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The Nproduct is the active species in both local and longrange signaling, whereas the Cproduct has no signaling activity. - Proteine/Peptide
