Human SIRP alphaV8 / CD172a Protein, His Tag (MALS verified), Unconjugated
Artikelnummer:
ABS-SI8-H52H5-100UG
Hersteller Artikelnummer:
SI8-H52H5-100ug
Alternativnummer:
ABS-SI8-H52H5-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Tyrosineprotein phosphatase nonreceptor type substrate 1 (SHPS1) is also known as CD172 antigenlike family member A (CD172a), Macrophage fusion receptor, MyD1 antigen, Signalregulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulinlike cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinasecoupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. - Proteine/Peptide
