Biotinylated Human CD96 / TACTILE Protein, His,Avitag(TM)
Artikelnummer:
ABS-TAE-H82E3-200UG
Hersteller Artikelnummer:
TAE-H82E3-200ug
Alternativnummer:
ABS-TAE-H82E3-200UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Biotin
The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the costimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA4 pathway, in which shared ligands and differential receptor:ligand affinities finetune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving antitumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and lowset, posteriorly rotated ears. - Proteine/Peptide
