Human TGF-Beta 1 / TGFB1 Protein, premium grade, Unconjugated
Artikelnummer:
ABS-TG1-H5218-1MG
Hersteller Artikelnummer:
TG1-H5218-1mg
Alternativnummer:
ABS-TG1-H5218-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
This gene encodes a secreted ligand of the TGFbeta (transforming growth factorbeta) superfamily of proteins. Ligands of this family bind various TGFbeta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latencyassociated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGFbeta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in CamuratiEngelmann disease. [provided by RefSeq, Aug 2016] - Proteine/Peptide
