TGFbeta receptor type2 (TGFBR2 or TGFR2) is also known as TGFbeta type II receptor, Transforming growth factorbeta receptor type II, TbetaRII, TGFbetaR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGFbeta1 / TGFB1 and TGFbeta3 / TGFB3 with high affinity and TGFbeta2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. - Proteine/Peptide
