Human TIM-4 / TIMD4 Protein, His Tag, Unconjugated
Artikelnummer:
ABS-TI4-H52H3-100UG
Hersteller Artikelnummer:
TI4-H52H3-100ug
Alternativnummer:
ABS-TI4-H52H3-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. An essential step during clearance of apoptotic cells is the recognition of phosphatidylserine (PS) exposed on apoptotic cells by its receptors on phagocytes. The phosphatidylserine (PS) receptor Tim4 mediates phagocytosis of apoptotic cells by binding to PS exposed on the surface of these cells, and thus functions as a PS receptor for apoptotic cells. Tim4 directly binding to PS and functioning as a tethering receptor for phagocytosis of apoptotic cells has been extensively studied over the past decade. However, the molecular mechanisms by which Tim4 collaborates with other engulfment receptors during efferocytosis remain elusive. - Proteine/Peptide
