Biotinylated Human TIGIT Protein, Fc,Avitag(TM) (MALS verified)

Produktübersicht

• Artikelname: Biotinylated Human TIGIT Protein, Fc,Avitag(TM) (MALS verified)
• Artikelnummer: ABS-TIT-H82F1-25UG
• Hersteller Artikelnummer: TIT-H82F1-25ug
• Alternativnummer: ABS-TIT-H82F1-25UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Biotin

Produktbeschreibung

Tcell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as Vset and immunoglobulin domaincontaining protein 9 (VSIG9), Vset and transmembrane domaincontaining protein 3 (VSTM3),which belongs to singlepass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosinebased inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ Tcells and NK cells and is upregulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses Tcell activation by promoting the generation of mature immunoregulatory dendritic cells. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 41.3 kDa
• Tag: C-Fc & C-Avi
• NCBI: 495
• Puffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TIGIT

Bilder

Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 5 µg/mL (100 µL/well) can bind Biotinylated Human TIGIT, Fc,Avitag (Cat. No. TIT-H82F1) with a linear range of 10-156 ng/mL (QC tested).

Serial dilutions of Human TIGIT Neutralizing antibody were added into Human CD155, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD5-H5254): Biotinylated Human TIGIT, Fc,Avitag (Cat. No. TIT-H82F1) binding reactions. The half maximal inhibitory concentration (IC50) is 0.08116 µg/mL (Routinely tested).

TIT-H82F1-25ug

Biotinylated Human TIGIT, Fc,Avitag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.