Human TLR3 Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human TLR3 Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-TL3-H5253-100UG
• Hersteller Artikelnummer: TL3-H5253-100ug
• Alternativnummer: ABS-TL3-H5253-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Tolllike receptor 3 (TLR3) is also known as CD283, which belongs to the Tolllike receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs (Tolllike receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 / CD283 contains 22 LRR (leucinerich) repeats, 1 LRRCT domain, 1 LRRNT domain and 1 TIR domain. TLR3 is expressed at high level in placenta and pancreas and also detected in CD11c+ immature dendritic cells. CD283 / TLR3 is only expressed in dendritic cells. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. CD283 / TLR3 is the key component of innate and adaptive immunity. TLR3 / CD283 is a nucleotidesensing TLR which is activated by doublestranded RNA, a sign of viral infection. TLR3 acts via MYD88 and TRAF6, leading to NFkappaB activation, cytokine secretion and the inflammatory response. Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2). - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 103.8 kDa
• Tag: C-Fc
• NCBI: 6
• Puffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TLR3

Bilder

Human TLR3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.