Rhesus macaque TLR3 / CD283 Protein, Fc Tag (MALS verified), Unconjugated, Human
Artikelnummer:
ABS-TL3-R5253-100UG
Hersteller Artikelnummer:
TL3-R5253-100ug
Alternativnummer:
ABS-TL3-R5253-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Unconjugated
Tolllike receptor 3 (TLR3) is also known as CD283, which belongs to the Tolllike receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs (Tolllike receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 / CD283 contains 22 LRR (leucinerich) repeats, 1 LRRCT domain, 1 LRRNT domain and 1 TIR domain. TLR3 is expressed at high level in placenta and pancreas and also detected in CD11c+ immature dendritic cells. CD283 / TLR3 is only expressed in dendritic cells. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. CD283 / TLR3 is the key component of innate and adaptive immunity. TLR3 / CD283 is a nucleotidesensing TLR which is activated by doublestranded RNA, a sign of viral infection. TLR3 acts via MYD88 and TRAF6, leading to NFkappaB activation, cytokine secretion and the inflammatory response. Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2). - Proteine/Peptide
