Human TNFR2 / CD120b / TNFRSF1B Protein, His Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human TNFR2 / CD120b / TNFRSF1B Protein, His Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-TN2-H5227-50UG
• Hersteller Artikelnummer: TN2-H5227-50ug
• Alternativnummer: ABS-TN2-H5227-50UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

TNF RI is also known as the p60 or p55 TNFR) and TNF RII (the p75 or p80 TNFR) are two distinct type I transmembrane glycoproteins that bind TNF with highaffinity.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B, respectively. Human TNF RII cDNA encodes a 461 amino acid (aa) residue precursor protein with a 22 aa putative signal peptide, a 235 aa extracellular domain, a 20 aa transmembrane domain and a 174 aa cytoplasmic domain. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFalpha action by competing with cell surface receptors in binding TNFalpha, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 26.0 kDa
• Tag: C-6*His
• NCBI: 36755
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TNFR2

Bilder

Immobilized Human TNF-alpha, premium grade (Cat. No. TNA-H4211) at 5 µg/mL (100 µL/well) can bind Human TNFR2, His Tag (Cat. No. TN2-H5227) with a linear range of 5-39 ng/mL (QC tested).

Immobilized ActiveMax Human TNF-beta, Tag Free at 5 µg/mL (100 µL/well) can bind Human TNFR2, His Tag (Cat. No. TN2-H5227) with a linear range of 2-62 ng/mL (Routinely tested).

Human TNFR2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.