Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag (MALS verified), Unconjugated, Human

Produktübersicht

• Artikelname: Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag (MALS verified), Unconjugated, Human
• Artikelnummer: ABS-TR2-C52H7-1MG
• Hersteller Artikelnummer: TR2-C52H7-1mg
• Alternativnummer: ABS-TR2-C52H7-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Monkey
• Konjugation: Unconjugated

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNFrelated apoptosisinducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNFreceptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAILR2 / TNFRSF10B recruits caspase8 to the activated receptor. The resulting deathinducing signaling complex (DISC) performs caspase8 proteolytic activation which initiates the subsequent cascade of caspases (aspartatespecific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NFkappaB. DR5 is essential for ER stressinduced apoptosis and is regulated by p53/TP53. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 19.1 kDa
• Tag: C-10*His
• NCBI: 0
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: TRAIL R2

Bilder

Immobilized Cynomolgus TRAIL R2, His Tag (Cat. No. TR2-C52H7) at 5 µg/mL (100 µL/well) can bind Human TRAIL, Mouse IgG2a Fc Tag with a linear range of 2-63 ng/mL (QC tested).

TR2-C52H7-1mg

Cynomolgus TRAIL R2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.