Human TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag, Unconjugated
Artikelnummer:
ABS-TR2-H5229-100UG
Hersteller Artikelnummer:
TR2-H5229-100ug
Alternativnummer:
ABS-TR2-H5229-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNFrelated apoptosisinducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNFreceptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAILR2 / TNFRSF10B recruits caspase8 to the activated receptor. The resulting deathinducing signaling complex (DISC) performs caspase8 proteolytic activation which initiates the subsequent cascade of caspases (aspartatespecific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NFkappaB. DR5 is essential for ER stressinduced apoptosis and is regulated by p53/TP53. - Proteine/Peptide
